| Kolo | Datum | Domácí - Hosté | Skóre |
|---|
| 1.kolo | 4.9.2021, 17:00 | DHC Slavia Praha - DHC Sokol Poruba | 24:30 (13:17) |
| 2.kolo | 11.9.2021, 18:00 | DHC Sokol Poruba - Sokol Písek | 29:30 (17:15) |
| 3.kolo | 18.9.2021, 15:00 | DHC Plzeň - DHC Sokol Poruba | 28:17 (14:7) |
| 4.kolo | 26.9.2021, 18:00 | DHC Sokol Poruba - DHK Zora Olomouc | 23:30 (9:13) |
| 5.kolo | 2.10.2021, 15:00 | HK Slovan Duslo Šaľa - DHC Sokol Poruba | 35:22 (21:13) |
| 6.kolo | 17.10.2021, 18:00 | KPR RUCH Chorzów - DHC Sokol Poruba | 32:34 (15:16) |
| 7.kolo | 24.10.2021, 17:00 | DHC Sokol Poruba - AHT HC Tatran Stupava | 37:12 (18:3) |
| 8.kolo | 30.10.2021, 16:00 | Házená Kynžvart - DHC Sokol Poruba | 36:27 (22:13) |
| 9.kolo | 3.11.2021, 18:00 | DHC Sokol Poruba - HK Hodonín | 35:20 (15:11) |
| 10.kolo | 6.11.2021, 17:30 | DHK Baník Most - DHC Sokol Poruba | 33:26 (18:11) |
| 11.kolo | 10.11.2021, 18:00 | DHC Sokol Poruba - MŠK Iuventa Michalovce | 21:31 (12:18) |
| 12.kolo | 17.11.2021, 18:00 | HC DAC Dunajská Streda - DHC Sokol Poruba | 28:20 (17:7) |
| 13.kolo | 8.1.2022, 18:00 | DHC Sokol Poruba - Handball PSG Zlín | |
| 14.kolo | 16.1.2022, 17:00 | DHC Sokol Poruba - DHC Slavia Praha | |
| 15.kolo | 22.1.2022, 0:00 | Sokol Písek - DHC Sokol Poruba | |
| 16.kolo | 30.1.2022, 17:00 | DHC Sokol Poruba - DHC Plzeň | |
| 17.kolo | 5.2.2022, 0:00 | DHK Zora Olomouc - DHC Sokol Poruba | |
| 18.kolo | 12.2.2022, 0:00 | DHC Sokol Poruba - HK Slovan Duslo Šaľa | |
| 19.kolo | 19.2.2022, 0:00 | DHC Sokol Poruba - KPR RUCH Chorzów | |
| 20.kolo | 26.2.2022, 0:00 | AHT HC Tatran Stupava - DHC Sokol Poruba | |
| 21.kolo | 12.3.2022, 0:00 | DHC Sokol Poruba - Házená Kynžvart | |
| 22.kolo | 19.3.2022, 0:00 | HK Hodonín - DHC Sokol Poruba | |
| 23.kolo | 26.3.2022, 0:00 | DHC Sokol Poruba - DHK Baník Most | |
| 24.kolo | 2.4.2022, 0:00 | MŠK Iuventa Michalovce - DHC Sokol Poruba | |
| 25.kolo | 9.4.2022, 0:00 | DHC Sokol Poruba - HC DAC Dunajská Streda | |
| 26.kolo | 13.4.2022, 0:00 | Handball PSG Zlín - DHC Sokol Poruba | |
